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KMID : 1022920210090010037
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Journal of Korean Academy of Social & Managed Care Pharmacy
2021 Volume.9 No. 1 p.37 ~ p.47
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Comparative Effectiveness of Smoking Cessation Intervention with Pharmacist-delivered Service: Systematic Review and Bayesian Network Meta-analysis
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Kang Dong-Won
Lee Eui-Kyung
Park Sun-Kyeong
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Abstract
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OBJECTIVES: This study aims to estimate and compare the smoking cessation rate of pharmacist-delivered support with nicotine replacement therapy (hereafter, pharmacist support + NRT) by conducting a systematic review and Bayesian network meta-analysis (BNMA).
METHODS: We systematically reviewed the articles, which reported the smoking cessation rate for 1) pharmacist support + NRT, 2) varenicline with non-pharmacist support, 3) NRT with non-pharmacist support to identify the relevant studies. Searched studies from Pubmed and Cochrane library were selected according to the pre-defined inclusion/exclusion criteria. We extracted the smoking cessation rate at 6 months from included studies. This BNMA estimated the posterior average smoking cessation rate at 6 months and the corresponding 95% credible interval (CrI). We conducted the BNMA by using WinBUGS 1.4.3.
RESULTS: After comprehensive systematic review, we finally selected and included 33 studies in BNMA. Average smoking cessation rate at 6 months was the lowest for placebo (16.6%; 95% CrI=15.4%-17.8%) as followed by NRT + non-pharmacist support (28.5%; 95% CrI=23.0%-34.7%), pharmacist support + NRT (36.1%; 95% CrI=25.1%-48.8%), and varenicline + non-pharmacist support (37.7%; 95% CrI=32.0%- 44.1%].
CONCLUSION: In this study, we estimated the smoking cessation rate of pharmacist service with NRT, NRT and varenicline, respectively. We expect that the results of this study will be used as a useful evidence for establishing policies for various types of smoking cessation services.
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KEYWORD
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pharmaceutical services, smoking cessation, network meta-analysis
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